Osteomalacia after Prolonged Glutethimide Administration

Osteomalacia after prolonged glutethimide administration.

Vitamin D deficiency is a previously unreported complication of therapy with hypnotics, and we here report a case of osteomalacia associated with long-term glutethimide administration. There was evidence of pronounced hepatic enzyme induction, and the plasma half-time of (3)H vitamin D(3) was decreased by this drug. In addition, raised levels of serum gamma-glutamyl transpeptidase, 5-nucleotida...

Oral bioavailability of ATP after prolonged administration.

Purinergic receptors are important for the regulation of inflammation, muscle contraction, neurotransmission and nociception. Extracellular ATP and its metabolites are the main ligands for these receptors. Occasional reports on beneficial results of ATP administration in human and animal studies have suggested the bioavailability of oral ATP supplements. We investigated whether prolonged daily ...

Endometrial changes after prolonged progesterone and testosterone administration to rabbits.

Neurological effects of glutethimide.

Thalidomide in its heyday commonly produced neuropathy. The chemical similarity of the frequently used sedative glutethimide (Doriden) to thalidomide prompted Fullerton and Kremer (1961) to say, 'It is interesting that similar toxic effects have not been reported in patients taking glutethimide . . .'. Since this statement, three authors have reported a total of four cases of nervous system dam...

Recovery in severe glutethimide poisoning.

for it was largely intra-thoracic and yet the tear was limited to the oesophago-gastric junction. It is suggested here that there is occasionally a failure of relaxation of the lower oesophagus which raises the pressure gradient to a sufficient degree to cause a tear, for the lower oesophagus normally relaxes during vomiting and in this patient the gastrografin swallow showed evidence of abnorm...